Does the LED blink green when you press PTT on your radio?
Have you used the Quick Setup to set up the connection to the BrandMeister Network?
What transceiver do you have? If it does not have a half deviation on/off option, then it is transmitting in C4FM half deviation, so make sure you use the C4FM Half Deviation modem mode in the openSPOT2 and run AutoCal.
Please also take a look at the C4FM/Fusion radio setup section in the user manual:
http://manuals.sharkrf.com/openspot2/en/setting-up-your-transceiver.html#c4fmfusion-radio-setup